Importantly, P-selectin-mediated binding of SCLC to endothelial cells has already been shown in vitro (Pottratz et al, 1996) and the CD24/P-selectin pathway was found to initiate lung colonisation of the human lung adenocarcinoma cell line A125 in a mouse model (Friederichs et al, 2000). This evidence concerns the gene SELP and lung adenocarcinoma.