We previously demonstrated that expression of an actin-regulatory protein (Yin and Stossel, 1979), gelsolin, is frequently downregulated in lung cancer (Dosaka-Akita et al, 1998) and several types of different human cancers, such as stomach, bladder and colon (Moriya et al, 1994; Tanaka et al, 1995; Furuuchi et al, 1996). The gene discussed is GSN; the disease is lung cancer.