GSN and malignant colon neoplasm: We previously reported that gelsolin expression is reduced or not detected in various lung cancer cell lines and in more than half of the surgically resected tissues (Dosaka-Akita et al, 1998), and demonstrated that ectopic expression of gelsolin cDNA in bladder and colon cancer cell lines results in suppression of tumorigenicity (Tanaka et al, 1995; Furuuchi et al, 1996).