Of these 65 tumours, 57 (26 adenocarcinomas and 31 squamous cell carcinomas) showed immunostaining of both the neoplastic emboli and of the invasive neoplastic nests, whereas eight out of 65 tumours (all adenocarcinomas) did not show any fascin immunoreactivity in either component (P<0.001). The gene discussed is FSCN1; the disease is squamous cell carcinoma.