In normal epithelial cells, the fascin-1 expression level (later on indicated as fascin only) is usually low, but is often upregulated in several types of human neoplasms, such as breast (Sun et al, 1997; Grothey et al, 2000a, b; Guvakova et al, 2002), ovary (Hu et al, 2000) and pancreas carcinomas (lacobuzio-Donahue et al, 2002; Maitra et al, 2002), and skin tumours (Goncharuk et al, 2002). This evidence concerns the gene FSCN1 and neoplasm.