Some studies have suggested that Her-2/Neu overexpression may increase fascin mRNA and protein levels in human breast cancer cell lines (Grothey et al, 2000a), but we have been unable to find any association between fascin and Her-2/Neu protein or gene status in our series of NSCLC, using both immunohistochemistry for protein overexpression and FISH analysis for gene amplification or polysomy (data not shown). The gene discussed is FSCN1; the disease is breast cancer.