The validation of differentially expressed fascin levels in NSCLC could open new diagnostic and therapeutic perspectives, such as the development of radiologic imaging systems based on tagged antibody strategy to detect small lung cancers, either primary or metastatic, or the strategy of cell-mediated or antibody-based immunotherapy using fascin for targeting more aggressive lung carcinomas. This evidence concerns the gene FSCN1 and non-small cell lung carcinoma.