TP53 and breast carcinoma: Engagement of apoptotic machinery (induction of apoptosis-initiating receptor CD95/FAS1, upregulation of P53 and P21, downregulation of Bcl-2; Monks et al, 2001; Chua et al, 1999a,1999b) and detection of DNA single-strand breaks has been observed in responsive mammary carcinoma cells when challenged with benzothiazole analogues (Bradshaw et al, 2000).