Sex, age, time from diagnosis of tumour to metastatic disease, the presence of lung, brain or other metastases, ESR, haemoglobin level, and IL-2-pretreatment were also tested, but rendered not significant by univariate analysis after correction (where necessary) of P-values by using the formula of Miller and Siegmund (1982) (see also Altman et al, 1994). This evidence concerns the gene IL2 and metastatic neoplasm.