The fact that normal cells, compared to malignant cells, appear to overexpress DcR-1 and DcR-2 and/or FLIP suggest that TRAIL-induced apoptosis may be selective for cancer cells (Bonavida et al, 1999; Kim et al, 2000), making TRAIL attractive as a potential anticancer agent (Nagane et al, 2001). This evidence concerns the gene TNFSF10 and cancer.