Our observation that suppression of EWS/FLI-1-activated genes inhibits transformation in vitro and in vivo is consistent with previous studies, which demonstrated that expression of a FLI-1 DBD can suppress Ewing's sarcoma and EWS/FLI-1-transformed cell growth in vitro (Kovar et al, 1996; Welford et al, 2001), presumably by competing with EWS/FLI-1 DNA binding. Here, EWSR1 is linked to Ewing sarcoma.