Although previous studies observed a significant interaction between GSTM1-null, GSTT1-null genotypes and alcohol consumption in the risk for breast cancer among premenopausal women (Park et al, 2000) and among both pre- and postmenopausal women (Helzlsouser et al, 1998), the potential association between individual GSTM1 alleles and breast cancer or their interaction with alcohol consumption in modifying the risk of breast cancer was not investigated. This evidence concerns the gene GSTM1 and breast carcinoma.