A nearly 10-fold higher serum than plasma VEGF-A level is found in both cancer patients as in healthy persons (Banks et al, 1998), indicating that circulating VEGF-A is mainly blood cell associated, in particular in platelets (Verheul et al, 1997; Salgado et al, 1999; Gunsilius et al, 2000). This evidence concerns the gene VEGFA and cancer.