Shim et al (2001) recently demonstrated that overexpression of antisense Ang-1 mRNA by HeLa cells inhibited angiogenesis and xenografted tumour growth in immunodeficient mice. An increased neovascularisation effect by Ang-1 overexpression was also described by Suri et al (1998) using a transgenic mouse model. This evidence concerns the gene ANGPT1 and neoplasm.