Based on our preliminary observations about the presence of COX-2 staining in the stroma compartment of cervical tumours we were then prompted at providing a more in depth analysis of (i) COX-2 content in the stroma inflammatory cellular elements of this neoplasia, (ii) the relationship between COX-2 expression in tumour cells vs stroma inflammatory compartment, and (iii) the possible clinical role of COX-2 expression according to the cellular compartment of staining. The gene discussed is PTGS2; the disease is neoplasm.