CAV1 and neoplasm: Under some conditions, caveolin-1 has been shown to suppress growth of specific cell lines in vitro and in vivo (Koleske et al, 1995; Engelman et al, 1997; Suzuki et al, 1998), and some have suggested that caveolin-1 functions as a tumour suppressor gene (Engelman et al, 1998b).