On the other hand, caveolin-1 has been reported as a tumour suppressor gene (Engelman et al, 1998b) and its expression level is reduced in several cancers (Lee et al, 1998; Racine et al, 1999; Bender et al, 2000; Wiechen et al, 2001a,b). The gene discussed is CAV1; the disease is neoplasm.