SRC and colonic neoplasm: Although the mode of increased c-Src expression and activity is not well understood, and may vary from cancer to cancer, it has been associated with different stages of colon tumour development, including metastasis (Bolen et al, 1987; Cartwright et al, 1989, 1990; Talamonti et al, 1993; Mao et al, 1997).