In this regard, c-Src co-operates with migratory growth factors, including epidermal growth factor (EGF), both to induce epithelial cell migration (Rodier et al, 1995), as well as to induce hepatocyte growth factor (HGF)- or EGF-induced invasion of colon cancer cells in vitro (Brunton et al, 1997; Empereur et al, 1997). This evidence concerns the gene SRC and malignant colon neoplasm.