Like TPA, the concentration of CA125 in the sera or in tumour cell cytosols of lung cancer patients has been found increased in the most advanced stages of disease (Diez et al, 1991; Kimura et al, 1990; Picardo et al, 1994) and prognostically significant (Diez et al, 1994, 1996). Here, PLAT is linked to neoplasm.