The direct relation between ER or PgR and bcl-2 (rs=0.38, P=0.001 and rs=0.40, P=0.001, respectively), VEGF and tumour size or number of metastatic lymph nodes (rs=0.33, P=0.001 and rs=0.27, P=0.01, respectively), TLI and p21waf1 (rs= 0.28, P=0.03) seemed to be independent of p53 expression, since they were observed in the subset of p53-negative IDC, as well as in the overall IDC series. Here, TP53 is linked to neoplasm.