Conversely, the higher incidence of p53+ IDC compared to ILC, associated with a higher VEGF concentration, is in keeping with a possible down-regulation of angiogenesis by p53 tumour suppressor gene function through a block of HIF-1 activity, with the formation of a stable complex wild-type p53/HIF-1α (An et al, 1998) and the subsequent ubiquitination of HIF-1α. Here, HIF1A is linked to neoplasm.