Conversely, a direct correlation between p21waf1 and cyclin A (P=0.03), between p16ink4A and tumour size (P=0.03), between VEGF and HIF-1α (P=0.05) and between p27kip1 and ER (P=0.05) was present only in ILC. This evidence concerns the gene CDKN2A and neoplasm.