The overall series of 257 invasive breast cancers can be considered representative of the bio-profile of human breast cancers, for the presence of ER and PgR in 84 and 69% of the cases, respectively, the prevalence of cases not expressing p53 (about 81%), and the presence of a similar fraction of bcl-2-positive and negative cases, in agreement with published results on larger series of cases. This evidence concerns the gene PGR and invasive breast carcinoma.