Summarizing data from all cycles of HD-VIP chemotherapy the number of patients with Hb level <10 g dl−1 was 99% and the median Hb nadir value was 7.8 g dl−1 demonstrating the significant degree of anaemia associated with this dose intensified chemotherapy approach despite the frequent use of RBC transfusions. Here, GSTM1 is linked to anemia (phenotype).