Functional SNPs in the TNF-α promoter (−308G>A and –238G>A), in the 3′UTR of the VEGF gene (936C>T) (Balasubramanian et al, 2002) and in exon 42 of the Endostatin gene (G>A change) are not associated with breast cancer. This evidence concerns the gene COL18A1 and breast carcinoma.