AKT1 and cancer: These data together with our chemosensitisation studies indicate, that Akt may have a dual role in tumorigenesis: Early in the process of malignant transformation Akt may prevent anoikis when immortalised cells leave their original cellular context to extravasate into a different environment and later to protect cancer cells from unfavourable conditions of e.g. poor nutrient supply and low oxygen to transmit strong survival signals.