TYMS and neoplasm: In particular, in a cohort of 330 patients enrolled onto two randomised studies and given 5-FU-containing chemotherapeutic associations with different modulators (levamisole, folinic acid, methotrexate), MVD, VEGF expression, cytofluorimetrically-determined nuclear DNA content (ploidy), tumour lymphocyte infiltration and TS expression were analysed together with conventional clinico-pathological variables.