Investigation of latent TGF-β1 as a possible integrin ligand led to the discovery that A549 lung adenocarcinoma cells adhere to LAP-β1 using αvβ1 and αvβ5 integrins (but migrate on LAP using αvβ1) (Munger et al, 1998). The gene discussed is TGFB1; the disease is lung adenocarcinoma.