CCND1 and tarsal-carpal coalition syndrome: Following on from previous studies within this laboratory (Bartlett et al, 1998, 1999; Watters et al, 2000, 2001) which associated specific chromosomal aberrations with recurrence or progression, we hypothesised that alteration of key cell cycle modulators c-myc and CCND1 via gene alterations drives progression of superficial and locally invasive TCC (pTa/pT1).