Since there was a particularly large variability in the expression of rhoB and rhoC mRNAs in tumours (see Figure 3C), and having in mind a previous report indicating that rhoC mRNA expression is related to malignancy of pancreas tumours (Suwa et al, 1998a), we also examined whether rhoB and rhoC mRNA expression is related to histological grading. The gene discussed is RHOC; the disease is medical procedure.