Currently, different antibodies to three endothelial cell antigens can be used to visualise the tumour blood vessels by immunohistochemistry: factor VIII antigen or von Willebrand's factor is involved in platelet adhesion and aggregation; CD31 or PECAM 1 (platelet/endothelial cell adhesion molecule) is associated with platelet adhesion in inflammation, wound healing, trans-endothelial cell migration and cell migration; CD34 is involved in leukocyte adhesion and endothelial cell migration during angiogenesis. The gene discussed is CD34; the disease is neoplasm.