Yano et al (2000) found that correlation between factor VIII and CD34 staining for MVC was not strong and that staining for CD 34 significantly correlated with survival in adenocarcinoma but staining for factor VIII did not. Duarte et al (1998) reported that CD 31 did not predict survival in stage I NSCLC and did not correlate strongly with factor VIII which is correlated with lung cancer death. Giatromanolaki et al (1997) concluded that CD31 is sensitive for highlighting small, immature microvessels and is better correlated with nodal involvement and overall survival than factor VIII. This evidence concerns the gene PECAM1 and lung carcinoma.