However, the finding that the Fas/Fas-L interaction suppressed lung metastasis of melanoma in murine models argued against a major contribution of tumour Fas-L in escape from immune surveillance (Owen-Schaub et al, 1998; Rivoltini et al, 1998; Sprecher et al, 1999) and suggested a negative role of Fas-associated apoptosis in metastasis. This evidence concerns the gene FASLG and melanoma.