TP53 and neoplasm: In an attempt to rely on inherent biological characteristics of the tumours, only the 86 patients treated with a doxorubicin-containing adjuvant regimen prior to HDCT therapy were to be analysed for outcome; two specimens from these patients were inadequate for p53 and HER2/staining; hence, only 84 of the 90 patients with tumour blocks were included in this subsequent analysis.