The proportion of tumour haemorrhagic necrosis in mice treated with DMXAA (25 mg kg−1) was 99% in WT and 76% in TNFR1−/− mice, but at higher doses, tumours in TNFR1−/− mice exhibited a similar degree of necrosis (Table 2). This evidence concerns the gene TNFRSF1A and neoplasm.