TNFRSF1A and neoplasm: A higher dose of DMXAA does induce tumour regressions in TNFR1−/− mice (Table 2) and although time courses for 5HIAA production at higher doses have not been carried out, the dose response measured after 24 h increases markedly (Figure 2C), consistent with the generation of a sustained 5HIAA response in TNFR1−/− mice at high dose.