CXCL10 and neoplasm: The nature of the agent(s) involved is currently unknown, but other agents known to induce tumour haemorrhagic necrosis include interferons α/β (Dvorak and Gresser, 1989), interleukin-1α (Johnson et al, 1991), IP-10 (Sgadari et al, 1996), serotonin (Manda et al, 1988) and nitric oxide (Fukumura et al, 1997).