MLH1 and neoplasm: Mori et al (2001) reported an association between Msh2 absence and FHIT alterations in CRCs but did not analyse Mlh1 expression. Moreover, as the mechanisms of this hypothesis, they proposed that the repetitive elements, such as (CA)n and (A)n repeats, in introns 4 and 5 of the FHIT gene could be a target of damage in MMR deficient tumours.