Recently, a new candidate TSG located in this region, the human RAS effector homologue (termed RASSF1A) gene, has been shown to have tumour suppressing function and undergoes epigenetic inactivation in several cancers (Dammann et al, 2000; Burbee et al, 2001; Dreijerink et al, 2001). This evidence concerns the gene RASSF1 and neoplasm.