Both selective COX-2 (celecoxib) and non selective COX inhibition (ibuprofen) reduced the incidence and subsequent growth of primary breast tumours induced by 7,12-dimethylbenz(a)anthracene (DMBA) in female Sprague Dawley rats (Alshafie et al, 2000; Harris et al, 2000). The gene discussed is PTGS2; the disease is breast neoplasm.