In particular, centrosomal aberrations have been correlated with a number of different genetic abnormalities in tumours, e.g. amplification of STK15 (Zhou et al, 1998), mutations in TP53 (Carroll et al, 1999), and inactivation of BRCA1 (Xu et al, 1999), BRCA2 (Tutt et al, 1999), and GADD45 (Hollander et al, 1999). Here, BRCA1 is linked to neoplasm.