Furthermore, other oncogenes or tumour suppressors function through direct or indirect derregulation of p53 or pRb pathways such as MDM2, p14/19ARF, p33ING1, BMI-1, BRCA1, or viral oncogenes as HPV E6/E7, E1a, E1b or SV40 T antigen. Here, TP53 is linked to neoplasm.