DAPK1 and neoplasm: DAPK is a pro-apoptotic serine/threonine kinase whose expression is induced by interferon-γ (Deiss et al, 1995), and whose inactivation by DNA methylation of its promoter region is associated with various human tumours (Kissil et al, 1997; Katzenellenbogen et al, 1999; Esteller, 2000; Kim et al, 2001; Tang et al, 2000; Dong et al, 2001).