VEGFA and neoplasm: While the inhibition of VEGF expression by vector mediated gene transfer of antisense RNA has been shown to lead to growth delays in several tumour models (Folkman and Shing, 1992; Belletti et al, 1999; Kang et al, 2000; Nakashima et al, 2000), the only reports of in vivo efficacy when using VEGF antisense oligonucleotides occurred in VEGF dependent tumour models (Masood et al, 1997, 2001).