Although, the in vitro studies indicated that treating Caki-1 tumour cells with VEGF mRNA targeted antisense PS-ODNs down-regulated VEGF protein production sufficiently to affect the proliferation and migration of endothelial cells, it was important to demonstrate that such treatments also could affect Caki-1 cell induction of angiogenesis in vivo. This evidence concerns the gene VEGFA and neoplasm.