TGFB3 and oral mucositis: Topical administration of recombinant human TGF-β3 has also been shown to attenuate the oral mucositis induced in hamsters by 5-Fluorouracil with a concomitant reduction in weight loss and shorter duration of oral mucositis (Sonis et al, 1997; Spijkervet and Sonis, 1998).