ED-B Fn is produced by a variety of tumour and endothelial cell lines and it was also found in a large number of breast, prostate and colorectal carcinoma tissue samples of mixed histotypes (Zardi et al, 1987; Kosmehl et al, 1996; Albrecht et al, 1999; Midulla et al, 2000). The gene discussed is FN1; the disease is neoplasm.