VEGFA and neoplasm: On the other hand, several therapeutic studies show that the inhibition of the biological activity and/or the production of VEGF suppresses tumour angiogenesis and growth in vivo (Kim et al, 1993; Kondo et al, 1993; Asano et al, 1995; Borgstrom et al, 1996; Cheng et al, 1996; Saleh et al, 1996; Im et al, 1999), suggesting that tumour-derived VEGF plays a crucial role for tumour neovascularisation in vivo.