VEGFA and neoplasm: Among them, VEGF is considered to be the pivotal factor in tumour neovascularisation, because it increases in endothelial-cell proliferation and migration (Leung et al, 1989; Connolly et al, 1989; Ferrara et al, 1992), enhancement of tumour growth in vivo (Kondo et al, 1993, 2000) and remodelling of perivascular matrices by augmenting proteinases such as matrix metalloproteinases (MMPs) (Fisher et al, 1994; Moses, 1997).