In gastric cancer patients who underwent surgical resection with or without adjuvant chemotherapy, several investigators have reported the prognostic significance of TS, MRP1, and P-gp with conflicting results (Endo et al, 1996a; Monden et al, 1997; Kuniyasu et al, 1998; Takebayashi et al; 1998; Suda et al, 1999; Choi et al, 2001). Here, TYMS is linked to gastric cancer.