MIB1 and adenoma: In contrast, MIB-1 may differentiate adenomas from carcinomas of the adrenal cortex and may predict the biological behaviour of adrenocortical CA (Suzuki et al, 1992; Goldblum et al, 1993; Sasano et al, 1995; Iino et al, 1997; Nakazumi et al, 1998).