Accordingly, a lack of relation and even an inverse association between Bcl-2 and p53 were found in breast carcinomas (Leek et al, 1994; Siziopiku et al, 1996; Viacava et al, 1999) and in parathyroid adenomas (Naccarato et al, 1998). This evidence concerns the gene TP53 and parathyroid gland adenoma.