The findings of dominant-negative HIF-1α-transfectants suggest that the disruption of the HIF-1 pathway may be an effective treatment for metastasis, in addition to the treatment of primary tumours through the inhibition of various genes necessary for the growth and metastasis of tumour cells in vivo, in accordance with the previous report (Kung et al, 2000). Here, HIF1A is linked to neoplasm.