However, in oesophageal carcinoma, similar to our results, cdc25A was accumulated both in cytoplasms and nuclei (Nishioka et al, 2001), and in ovarian carcinoma, its immunoreactivity was seen mainly in cytoplasms (Broggini et al, 2000), indicating that the localisation of this phosphatase depends on the origin of the carcinoma. This evidence concerns the gene CDC25A and carcinoma.