Promoter hypermethylation of CpG islands of tumour suppressor genes (p16, p14, and APC), DNA repair genes (hMLH1 and MGMT) and genes related to metastasis and invasion (E-cadherin, TIMP-3, and DAPK) has been shown in various cancers and is associated with the loss of expression (Yoshiura et al, 1995; Herfarth et al, 1999; Eads et al, 2001; Esteller et al, 2001a; Rosas et al, 2001, Zöchbauer-Müller et al, 2001). The gene discussed is MLH1; the disease is cancer.