MMP-2 (gelatinase A), MMP-9 (gelatinase B) (Sier et al, 1996), MMP-7 (matrilysin) (Honda et al, 1996) and MMP-14 (MT1-MMP) (Nomura et al, 1995) are over-expressed in human gastric cancer. The gene discussed is MMP7; the disease is gastric cancer.