Thus, expression of TP by cancer cells was shown in carcinomas of the breast (Fox et al, 1995a; Toi et al, 1995), lung (Koukourakis et al, 1997), head and neck (Giatromanolaki et al, 1998) and stomach (Giatromanolaki et al, 2000), whereas a predominant stromal cell TP expression was shown in colorectal (Takebayashi et al, 1996) and endometrial carcinomas (Sivridis et al, 1999), particularly at the invading tumour front. The gene discussed is TYMP; the disease is neoplasm.