Binding assays using 125I-labelled[Tyr4]BN confirmed the presence of BN/GRP receptors on U-87MG tumour membranes (Pinski et al, 1994) and demonstrated a high affinity binding of AN-215 to these receptors characterised by an IC50 value of 4.0±0.1 nM. This evidence concerns the gene GRP and neoplasm.