BRCA1 and cancer: Four key questions are addressed: (1) What are the levels of mental health problems and cancer related worry in a clinical cohort offered BRCA1/2 testing?; (2) Do women accurately estimate their risks of developing breast/ovarian cancer and are these related to cancer specific worry?; (3) What risk management behaviours do women engage in (or anticipate) and is this related to cancer worry and risk perception?; and (4) What is the motivation for predictive genetic testing and does this differ for men and women?