EGFR and cancer: Expression or overexpression of EGFR is frequently observed in human cancers including non-small cell lung cancer and hormone-refractory prostate cancer (Salomon et al, 1995), and over expression has been associated with poor prognosis in several cancer types, including breast (Sainsbury et al, 1987), pancreas (Dong et al, 1998) and laryngeal (Maurizi et al, 1996).