The smallest area of gain was 8q21, which is centromeric to the location of the proto-oncogene MYC. Gain of 8q, including the 8q21 region, has been previously documented in many different cancer types, the majority of which are not related to HPV infection (Kallioniemi et al, 1994; Prat et al, 2001; Shiraishi et al, 2001; van Dekken et al, 2001). This evidence concerns the gene MYC and cancer.