In human MM, VEGF and bFGF are secreted by tumour cells and the concentrations of these angiogenic factors are higher in more advanced disease (Vacca et al, 1998; Bellamy et al, 1999; Dankbar et al, 2000; Di Raimondo et al, 2000; Sezer et al, 2000; Van Riet et al, 2000). The gene discussed is FGF2; the disease is neoplasm.