In experimental models, the p53 protein was found to be a positive regulator of BAX transcription, also, the analysis of the p53/BAX apoptotic pathway in colorectal carcinomas showed potential prognostic value (Zhan et al, 1994; Miyashita and Reed, 1995; De Angelis et al, 1998; Simms et al, 1998; Sturm et al, 1999). The gene discussed is TP53; the disease is colorectal carcinoma.