Moreover, as reported for wild-type p53, BAI1 over-expression inhibited the expression of collagenase-1 (MMP-1), which is known to be a positive regulator of tumour angiogenesis (Sang, 1998), and was the only metalloproteinase we found to be expressed in Panc-1 cells. This evidence concerns the gene ADGRB1 and neoplasm.